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TA-01
CAS No. 1784751-18-3
TA-01( TA01 | TA 01 )
Catalog No. M12689 CAS No. 1784751-18-3
A potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
|
| 5MG | 88 | In Stock |
|
| 10MG | 160 | In Stock |
|
| 25MG | 296 | In Stock |
|
| 50MG | 492 | In Stock |
|
| 100MG | 655 | In Stock |
|
| 500MG | 1341 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTA-01
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively.
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DescriptionA potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively; inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.
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In VitroTA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration.
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In Vivo——
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SynonymsTA01 | TA 01
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCKIδ|CKI?|p38MAPkinase
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1784751-18-3
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Formula Weight351.3246
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Molecular FormulaC20H12F3N3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESFC1=CC=CC=C1C2=C(C3=CC=NC=C3)NC(C4=C(F)C=CC=C4F)=N2
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Chemical NamePyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Laco F, et al. J Mol Cell Cardiol. 2015 Mar;80:56-70.
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