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Home - Products - Metabolic Enzyme/Protease - Casein Kinase - LY-364947

LY-364947

CAS No. 396129-53-6

LY-364947( HTS 466284 | TGF-β RI Kinase Inhibitor )

Catalog No. M14364 CAS No. 396129-53-6

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 68 In Stock
25MG 131 In Stock
50MG 241 In Stock
100MG 354 In Stock
200MG 530 In Stock
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Biological Information

  • Product Name
    LY-364947
  • Note
    Research use only, not for human use.
  • Brief Description
    LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
  • Description
    LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HTS 466284 | TGF-β RI Kinase Inhibitor
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Casein Kinase
  • Recptor
    CK1δ| MLK-7K| TGFβRI| TGFβRII| RIPK2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    396129-53-6
  • Formula Weight
    272.3
  • Molecular Formula
    C17H12N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 1 mg/mL (3.67 mM)
  • SMILES
    C1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14
  • Chemical Name
    4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li HY, et al. J Med Chem, 2006, 49(6), 2138-2142.
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