Cart
sales@molnova.com
NCC007
CAS No. 2342583-66-6
NCC007( —— )
Catalog No. M24065 CAS No. 2342583-66-6
NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
|
| 10MG | 39 | In Stock |
|
| 25MG | 71 | In Stock |
|
| 50MG | 116 | In Stock |
|
| 100MG | 170 | In Stock |
|
| 200MG | 246 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNCC007
-
NoteResearch use only, not for human use.
-
Brief DescriptionNCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
-
DescriptionNCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
-
In Vitro——
-
In VivoNCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition. Animal Model:Adult C57BL/6J background male mice (8 weeks old)Dosage:5, 15 mM Administration:Infused into the lateral ventricle, constant dark conditionResult:Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM.
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetCasein Kinase
-
RecptorCKIα|CKIδ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2342583-66-6
-
Formula Weight447.5
-
Molecular FormulaC22H28F3N7
-
Purity>98% (HPLC)
-
SolubilityDMSO:120 mg/mL?(268.16mM;?Need ultrasonic)
-
SMILESCC(C1CC1)n1c(nc(NCCN(C)C)nc2NCc3cccc(C(F)(F)F)c3)c2nc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase I伪 and 未. J Med Chem. 2019 Feb 28;62(4):1989-1998.
molnova catalog
related products
-
A-3 hydrochloride
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
-
NMS-P715
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
-
D4476
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
