Juglone

Research use only, not for human use.

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.

Cell Cytotoxicity Assay Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Inhibited cell growth in a dose-dependent manner.Apoptosis Analysis Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Increased the number of early apoptotic cells.Western Blot Analysis Cell Line:SGC-7901 Concentration:5, 10, 15, 20 μM Incubation Time:24 h Result:Decreased the expression of Bcl-2 and increased the Bax protein.

Animal Model:High-fat diet rats modelDosage:0.25 or 1 mg/kg Administration:p.o.Result:Regulated the expression of s TNF-α, IL-1β and IL-6.Inhibited the TLR4 expression and NF-kappa activity.

Regianin | 5-Hydroxy-14-naphthoquinone

Cell Cycle/DNA Damage

DNA/RNA Synthesis

RNA polymerase

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481-39-0

174.15

C10H6O3

>98% (HPLC)

DMSO: 15 mg/mL;Ethanol: 15 mg/mL

Oc1cccc2C(=O)C=CC(=O)c12

5-hydroxynaphthalene-14-dione

(-20℃)

With Ice Pack

≥ 2 years