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CX-3543
CAS No. 865311-47-3
CX-3543( Quarfloxin | Itarnafloxin )
Catalog No. M16281 CAS No. 865311-47-3
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 223 | In Stock |
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| 2MG | 93 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 402 | In Stock |
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| 50MG | 548 | In Stock |
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| 100MG | 732 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCX-3543
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NoteResearch use only, not for human use.
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Brief DescriptionCX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus.
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DescriptionCX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.Blood Cancer Phase 2 Discontinued.
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In VitroQuarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines.Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.
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In Vivo——
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SynonymsQuarfloxin | Itarnafloxin
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number865311-47-3
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Formula Weight604.67
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Molecular FormulaC35H33FN6O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (8.27 mM)
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SMILESO=C(C1=CN2C3=C(C(N4C[C@H](C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
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Chemical Name5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61.
2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32.
3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.
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