Floxuridine

Research use only, not for human use.

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.

Cell Viability Assay Cell Line:Ovarian cancer cells Concentration:0-25 μM Incubation Time: 4, 8, 24 hours Result:Was potentiated the sensitivity by ?PARP inhibitors.Western Blot Analysis Cell Line:OVCAR-8 and SKOV3ip cells Concentration:300 μM Incubation Time: 4, 8, 24 hours Result:Induced phosphorylation of Chk1 and Chk2 in two ovarian cancer cell lines Cell Cycle Analysis Cell Line:A2780, SKOV3ip, OVCAR-5, and OVCAR-3 ovarian cancer cells Concentration:0.5, 1.0, 1.5, 2.0, and 2.5 μM Incubation Time:24 hours Result:Induced cell arrest at G1/S-phase period.

Animal Model:C57BL/6 mice injected with?S. aureus Dosage:0.5-1.25 mg/kg Administration:once per day for 7 days or single dose Result:Was a very potent inhibitor for S. aureus infection in vivo.

5-FDU | 5-Fluorodeoxyuridine | NSC 26740 | NSC 27640

Cell Cycle/DNA Damage

DNA/RNA Synthesis

Thymidylate synthase

Cancer

——

50-91-9

246.19

C9H11FN2O5

>98% (HPLC)

Ethanol: 10 mg/mL (40.61 mM); Water: 49 mg/mL (199.03 mM); DMSO: 49 mg/mL (199.03 mM)

O=C1NC(C(F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O

5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

(-20℃)

With Ice Pack

≥ 2 years