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PF4800567
CAS No. 1188296-52-7
PF4800567( PF 4800567 | PF-4800567 )
Catalog No. M19870 CAS No. 1188296-52-7
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
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| 10MG | 87 | In Stock |
|
| 25MG | 205 | In Stock |
|
| 50MG | 340 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF4800567
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NoteResearch use only, not for human use.
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Brief DescriptionPF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
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DescriptionPF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.(In Vitro):PF-4800567 is a potent and selective inhibitor of casein kinase 1 (CK1 ), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 shows inhibitory activity against CK1 and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1 -mediated PER3 nuclear localization mediated by CK1 and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.(In Vivo):PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.
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In VitroPF-4800567 is a potent and selective inhibitor of casein kinase 1(CK1), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 shows inhibitory activity against CK1 and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.
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In VivoPF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.
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SynonymsPF 4800567 | PF-4800567
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCK1ε
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Research Area——
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Indication——
Chemical Information
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CAS Number1188296-52-7
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Formula Weight359.8
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Molecular FormulaC17H18ClN5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 70 mg/mL
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SMILESNc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Walton KM et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.
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