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LH-846
CAS No. 639052-78-1
LH-846( LH846 | LH-846 | LH 846 )
Catalog No. M15424 CAS No. 639052-78-1
LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 141 | In Stock |
|
| 50MG | 230 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLH-846
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NoteResearch use only, not for human use.
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Brief DescriptionLH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
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DescriptionLH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
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In VitroLH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells.
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In Vivo——
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SynonymsLH846 | LH-846 | LH 846
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number639052-78-1
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Formula Weight316.81
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Molecular FormulaC16H13ClN2OS
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Purity>98% (HPLC)
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SolubilityDMSO: 45 mg/mL
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SMILESO=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3
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Chemical NameN-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-1
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