Cart
sales@molnova.com
Cyclothiazide
CAS No. 2259-96-3
Cyclothiazide( Cyclothiazide | Anhydron | Renazide | Valmiran )
Catalog No. M18266 CAS No. 2259-96-3
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 69 | In Stock |
|
| 25MG | 140 | In Stock |
|
| 50MG | 230 | In Stock |
|
| 100MG | 341 | In Stock |
|
| 200MG | 504 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCyclothiazide
-
NoteResearch use only, not for human use.
-
Brief DescriptionCyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
-
DescriptionCyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran) is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan. This agent is capable of inhibiting rapid desensitization of the ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors, thereby potentiating glutamate responses which may induce seizures activity. Cyclothiazide was also found to inhibit gamma-aminobutyric acid (GABA)-A receptors.
-
In Vitro——
-
In Vivo——
-
SynonymsCyclothiazide | Anhydron | Renazide | Valmiran
-
PathwayMetabolic Enzyme/Protease
-
TargetLDL
-
RecptorAMPA
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2259-96-3
-
Formula Weight389.9
-
Molecular FormulaC14H16ClN3O4S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (320.61 mM)
-
SMILESNS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl
-
Chemical Name3-(bicyclo[2.2.1]hept-5-en-2-yl)-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Kessler et al (2000) The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits.Neurosci.Lett. 287 161.
molnova catalog
related products
-
1,2,3,6-Tetragalloyl...
1,2,3,6-Tetragalloylglucose has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).
-
3'-Demethylnobiletin
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death.
-
Ligupurpuroside B
Ligupurpuroside B is a glycoside isolated from Ligustrum robustum, with antioxidant activity.
