3'-Demethylnobiletin

Research use only, not for human use.

3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death.

3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death.(In Vitro):In this study, we examined the effects of NOB metabolites, 3'-Demethylnobiletin, 4'-demethyl-NOB and 3', 4'-didemethyl-NOB and NOB analog, tangeretin, on SRs and adhesion molecules mRNA expression. 3'-Demethylnobiletin significantly suppressed CD36 expression, moreover, 4'-demethyl- and 3', 4'-didemethyl-NOB significantly suppressed TPA-induced expression of SR-A and LOX-1. Further, the suppressive effects of 4'-demethyl- and 3', 4'-didemethyl-NOB on the expression of CD36 mRNA were greater extent than parent NOB. The inhibitory effects of the metabolites toward TPA-induced SR mRNA expression are partly associated with the suppression of AP-1 and NF-kappaB transcriptional activities.

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3'-Hydroxy-5 | 3'-hydroxy-4',5,6,7,8-pentamethoxyflavone

Metabolic Enzyme/Protease

LDL

LDL

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112448-39-2

388.372

C20H20O8

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (257.49 mM)

COc1ccc(cc1O)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1

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(-20℃)

With Ice Pack

≥ 2 years