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Ochromycinone

CAS No. 111540-00-2

Ochromycinone( STA21 | Ochromycinone | NSC 628869 )

Catalog No. M17821 CAS No. 111540-00-2

STA-21 is a selective STAT3 inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ochromycinone
Note

Research use only, not for human use.
Brief Description

STA-21 is a selective STAT3 inhibitor.
Description

STA-21 is a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. STA-21 improved the clinical course of arthritis in IL-1Ra-KO mice. It increased not only the number of Treg cells but also the function of the Treg cells. It also suppressed Th17 cells and osteoclast formation. These data suggest that STA-21 might be an effective treatment for patients with RA.
In Vitro

——
In Vivo

——
Synonyms

STA21 | Ochromycinone | NSC 628869
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

STAT3
Research Area

Inflammation/Immunology
Indication

——

Chemical Information

CAS Number

111540-00-2
Formula Weight

306.31
Molecular Formula

C19H14O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.67 mg/mL (54.42 mM)
SMILES

CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O
Chemical Name

8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

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