Cucurbitacin D( —— )

Catalog No. M21908 CAS No. 3877-86-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Cucurbitacin D
Note

Research use only, not for human use.
Brief Description

Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23.
Description

Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP90
Research Area

——
Indication

——

CAS Number

3877-86-9
Formula Weight

516.67
Molecular Formula

C??H??O?
Purity

>98% (HPLC)
Solubility

DMSO : 110 mg/mL (212.90 mM; Need ultrasonic)
SMILES

C[C@@]([C@@](CC=C(C(C)1C)[C@@]2([H])C[C@H](O)C1=O)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)[C@@]4(C3)C
Chemical Name

——

1. Hall JA, et al. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. J Nat Prod. 2015 Apr 24;78(4):873-9.

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