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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - STA 2842

STA 2842

CAS No. 1046490-67-8

STA 2842( STA2842 )

Catalog No. M10232 CAS No. 1046490-67-8

STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    STA 2842
  • Note
    Research use only, not for human use.
  • Brief Description
    STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90.
  • Description
    STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90; induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1(-/-) primary kidney cells and in vivo; significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    STA2842
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1046490-67-8
  • Formula Weight
    550.66
  • Molecular Formula
    C29H38N6O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=NN=C(C2=CC(C(C)C)=C(O)C=C2O)N1C3=CC=C(CN4CCOCC4)C=C3)NCCN5CCOCC5
  • Chemical Name
    5-(2,4-dihydroxy-5-isopropylphenyl)-N-(2-morpholinoethyl)-4-(4-(morpholinomethyl)phenyl)-4H-1,2,4-triazole-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Seeger-Nukpezah T, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. 2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. 3. Smithline ZB, et al. PLoS One. 2014 Dec 4;9(12):e114403.
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