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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - DDO-5936

DDO-5936

CAS No. 2355377-13-6

DDO-5936( —— )

Catalog No. M24068 CAS No. 2355377-13-6

DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 76 In Stock
5MG 69 In Stock
10MG 122 In Stock
25MG 264 In Stock
50MG 381 In Stock
100MG 542 In Stock
200MG 734 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    DDO-5936
  • Note
    Research use only, not for human use.
  • Brief Description
    DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
  • Description
    DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
  • In Vitro
    DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47.
  • In Vivo
    DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group.DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. Animal Model:Mice Dosage:0~80 mg/kg Administration:P.o.Result:Showed a moderate effect at the high dose group.
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP90
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2355377-13-6
  • Formula Weight
    495.59
  • Molecular Formula
    C25H29N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (25.22 mM)
  • SMILES
    O=C(O)CN(C1=CC=C(NC2=NC(N3CCCC3)=NC=C2)C=C1)S(=O)(C4=C(C)C=C(C)C=C4C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer[J]. Journal of medicinal chemistry, 63(3):1281-1297.
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