Cart
sales@molnova.com
KML29
CAS No. 1380424-42-9
KML29( KML-29 | KML29 | KML 29 )
Catalog No. M17269 CAS No. 1380424-42-9
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
|
| 10MG | 73 | In Stock |
|
| 25MG | 158 | In Stock |
|
| 50MG | 231 | In Stock |
|
| 100MG | 341 | In Stock |
|
| 500MG | 803 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameKML29
-
NoteResearch use only, not for human use.
-
Brief DescriptionKML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor.
-
DescriptionKML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).
-
In VitroKML29 dose-dependently elevates brain 2-AG level up to10-fold without alteration in brain levels of anandamide, palmitoylethanolamide, and oleoylethanolamide.KML29 is a potent inhibitor of 2-AG hydrolysis, but did not affect AEA hydrolysis at any concentration tested.
-
In VivoKML29 enhibits antinociceptive activity without cannabimimetic side effects.KML29 (20 mg/kg) has a significant but modest protective effectagainst LPS-induced fever. Animal Model:C57Bl/6 mice.Dosage:1-40 mg/kg. Administration:P.O. single dose.Result:Selectively inhibited MAGL in mice.Animal Model:Wistar albino male rats.Dosage:20 mg/kg (+LPS E. coli O111:B4 (250 μg/kg, sc)).Administration:SC.Result:Administration of KML29 simultaneously with LPS E. coli O111:B4 significantly decreased ?T (with 5% type 1 error, 1.7 fold) compared to saline+LPS E. coli O111:B4. Administration of KML29 simultaneously with LPS E. coli O111:B4 resulted in decreased plateau phase of fever compared to LPS E. E. coli O111:B4+saline administration.
-
SynonymsKML-29 | KML29 | KML 29
-
PathwayNeuroscience
-
TargetGluR
-
RecptorMAGL
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number1380424-42-9
-
Formula Weight549.42
-
Molecular FormulaC24H21F6NO7
-
Purity>98% (HPLC)
-
SolubilityDMSO : 50 mg/mL. 91.01 mM; H2O : < 0.1 mg/mL
-
SMILESO=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(C(c2ccc3OCOc3c2)(O)c2cc3OCOc3cc2)CC1
-
Chemical Name1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
CBiPES hydrochloride
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of WT and mGlu(3) receptors.
-
GYKI 52466 dihydroch...
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
-
Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
