S 18986

Research use only, not for human use.

S 18986 is a selective, orally active, brain-penetrant positive allosteric modulator of AMPA-type receptors that enhances cognition in rodents by inducing the release of noradrenaline and acetylcholine in the rat hippocampus, subsequently improving object-recognition memory.

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.

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S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models .S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation.Animal Model:Middle-aged (14-15-months-old) mice Dosage:0.3, 1, and 10 mg/kg Administration: p.o.Result:Showed antiamnesic properties in middle-aged rodents.

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Neuroscience

GluR

GluR

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175340-20-2

224.28

C10H12N2O2S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (445.87 mM; Ultrasonic )

O=S1(=O)C=2C(N3[C@@](N1)(CCC3)[H])=CC=CC2

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(-20℃)

With Ice Pack

≥ 2 years