NCT-507( NCT507 )

Catalog No. M17019 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

NCT-507
Note

Research use only, not for human use.
Brief Description

NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1).
Description

NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases; also exhibits IC50 of 53 nM in MIA PaCa-2 Aldefluor cell-based assays; demonstrates target engagement in CETSA asssays, inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.
In Vitro

——
In Vivo

——
Synonyms

NCT507
Pathway

Metabolic Enzyme/Protease
Target

ALDH
Recptor

ALDH
Research Area

——
Indication

——

CAS Number

——
Formula Weight

494.994
Molecular Formula

C25H23ClN4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

1-(4-(6-chloro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)phenyl)cyclopropane-1-carbonitrile

1. Yang SM, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00270.

Calculator

molnova catalog