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DKM 3-42
CAS No. 164925-73-9
DKM 3-42( —— )
Catalog No. M12520 CAS No. 164925-73-9
DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDKM 3-42
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NoteResearch use only, not for human use.
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Brief DescriptionDKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1.
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DescriptionDKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity; impairs A549 serum-survival in a dose-responsive manner, significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of DKM 3-42 (50mg/kg ip) once per day.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetALDH
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RecptorALDH
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Research Area——
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Indication——
Chemical Information
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CAS Number164925-73-9
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Formula Weight207.317
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Molecular FormulaC13H21NO
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(=CCCC(=CCNC(=O)C=C)C)C
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Chemical Name(E)-N-(3,7-dimethylocta-2,6-dien-1-yl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381.
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