NCT-506( NCT506 )

Catalog No. M17018 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NCT-506
Note

Research use only, not for human use.
Brief Description

NCT-506 (NCT506) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1).
Description

NCT-506 (NCT506) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases; also exhibits IC50 of 77 nM in MIA PaCa-2 Aldefluor cell-based assays; demonstrates target engagement in CETSA asssay (EC50=5.59 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.
In Vitro

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In Vivo

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Synonyms

NCT506
Pathway

Metabolic Enzyme/Protease
Target

ALDH
Recptor

ALDH
Research Area

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Indication

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CAS Number

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Formula Weight

592.566
Molecular Formula

C27H24F4N4O5S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

1-(4-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)phenyl)cyclopropanecarbonitrile, TFA

1. Yang SM, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00270.

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