Obicetrapib( AMG-899 | AMG899 | TA-8995 | DEX-001 )

Catalog No. M16296 CAS No. 866399-87-3

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Product Name

Obicetrapib
Note

Research use only, not for human use.
Brief Description

Obicetrapib (AMG-899, TA-8995, DEX-001) is a potent, ora cholesteryl ester transfer protein (CETP) inhibitor for treatment of dyslipidaemia.
Description

Obicetrapib (AMG-899, TA-8995, DEX-001) is a potent, ora cholesteryl ester transfer protein (CETP) inhibitor for treatment of dyslipidaemia.Dyslipidemia Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

AMG-899 | AMG899 | TA-8995 | DEX-001
Pathway

Metabolic Enzyme/Protease
Target

CETP
Recptor

CETP
Research Area

Cardiovascular Disease
Indication

Dyslipidemia

CAS Number

866399-87-3
Formula Weight

722.609
Molecular Formula

C32H31F9N4O5
Purity

>98% (HPLC)
Solubility

——
SMILES

CCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C4=NC=C(C=N4)OCCCC(=O)O
Chemical Name

4-[2-[[3,5-bis(trifluoromethyl)phenyl]methyl-[(2R,4S)-1-ethoxycarbonyl-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinolin-4-yl]amino]pyrimidin-5-yl]oxybutanoic acid

1. Ford J, et al. Br J Clin Pharmacol. 2014 Sep;78(3):498-508. 2. Hovingh GK, et al. Lancet. 2015 Aug 1;386(9992):452-60.

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