SR17018( SR17018 | SR-17018 | SR 17018 )

Catalog No. M17433 CAS No. 2134602-45-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SR17018
Note

Research use only, not for human use.
Brief Description

SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
Description

SR17018 is an mu-opioid-receptor (MOR) agonist with an EC50 of 97 nM.
In Vitro

SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM. SR17018 shows no obvious effect on inducing βarrestin2 recruitment to the MOR at below 10 μM. SR17018 promotes signaling through G proteins or βarrestin2.
In Vivo

——
Synonyms

SR17018 | SR-17018 | SR 17018
Pathway

Metabolic Enzyme/Protease
Target

CETP
Recptor

μ-opioid receptor
Research Area

Neurological Disease
Indication

——

CAS Number

2134602-45-0
Formula Weight

410.72
Molecular Formula

C19H18Cl3N3O
Purity

>98% (HPLC)
Solubility

DMSO : 6.4 mg/mL. 15.58 mM;
SMILES

Clc3cc4NC(=O)N(C2CCN(Cc1ccc(Cl)cc1)CC2)c4cc3Cl
Chemical Name

5,6-dichloro-1-(1-(4-chlorobenzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

1.Schmid CL,etal.Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.Cell. 2017 Nov 16;171(5):1165-1175.

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