Cart
sales@molnova.com
DM-NOFD
CAS No. 865488-53-5
DM-NOFD( Dimethyl ester NOFD | N-oxalyl-d-phenylalanine )
Catalog No. M16287 CAS No. 865488-53-5
The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameDM-NOFD
-
NoteResearch use only, not for human use.
-
Brief DescriptionThe dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM.
-
DescriptionThe dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.
-
In Vitro——
-
In Vivo——
-
SynonymsDimethyl ester NOFD | N-oxalyl-d-phenylalanine
-
PathwayAngiogenesis
-
TargetHIF/HIF Prolyl-hydroxylase
-
RecptorHIF/HIF Prolyl-hydroxylase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number865488-53-5
-
Formula Weight265.265
-
Molecular FormulaC13H15NO5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(OC)[C@@H](CC1=CC=CC=C1)NC(C(OC)=O)=O
-
Chemical NameDimethyl N-oxalyl-d-phenylalanine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73.
2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.
molnova catalog
related products
-
Molidustat
Molidustat (BAY 85-3934) is an orally active small molecule inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 480 nM, 280 nM and 450 nM for PHD1, PHD2, and PHD3, respectively.
-
Daprodustat
A nove, orally active HIF-prolyl hydroxylase (PHD) inhibitor that stimulate endogenous EPO synthesis and induces effective erythropoiesis by non-EPO effects.
-
PX-478
A potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
