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PX-478
CAS No. 685898-44-6
PX-478( PX478 | PX 478 )
Catalog No. M15620 CAS No. 685898-44-6
A potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 77 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 204 | In Stock |
|
| 50MG | 271 | In Stock |
|
| 100MG | 425 | In Stock |
|
| 200MG | 625 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePX-478
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
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DescriptionA potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity; inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively; suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.Blood Cancer Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPX478 | PX 478
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF-1α
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number685898-44-6
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Formula Weight394.1215
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Molecular FormulaC13H20Cl4N2O3
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 35 mg/mL
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SMILESCl.Cl.N[C@@H](CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O |r,c:5,7,t:3|
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Chemical NameL-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, (Hydrochloride) (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Welsh S, et al. Mol Cancer Ther. 2004 Mar;3(3):233-44.
2. Jordan BF, et al. Neoplasia. 2005 May;7(5):475-85.
3. Koh MY, et al. Mol Cancer Ther. 2008 Jan;7(1):90-100.
4. Schwartz DL, et al. Mol Cancer Ther. 2009 Apr;8(4):947-58.
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