IOX4( PHD2 inhibitor IOX4 )

Catalog No. M10541 CAS No. 1154097-71-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

IOX4
Note

Research use only, not for human use.
Brief Description

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM.
Description

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases; inhibits prolyl hydroxylation and increases HIF-1α levels in cells (IC50=5.6 to 11.7 μM), also induces HIF-1α and HIF-2α expression in mice.
In Vitro

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In Vivo

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Synonyms

PHD2 inhibitor IOX4
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF/HIF Prolyl-hydroxylase
Research Area

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Indication

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CAS Number

1154097-71-8
Formula Weight

328.3
Molecular Formula

C15H16N6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (152.29 mM)
SMILES

CC(C)(C)OC(C1=CN=C(N2NC=C(N3C=CN=N3)C2=O)C=C1)=O
Chemical Name

1,1-dimethylethyl ester 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-3-pyridinecarboxylic acid

1. Chan MC, et al. PLoS One. 2015 Jul 6;10(7):e0132004.

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