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103D5R
CAS No. 773852-25-8
103D5R( —— )
Catalog No. M15924 CAS No. 773852-25-8
103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name103D5R
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NoteResearch use only, not for human use.
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Brief Description103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
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Description103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity; shows cell proliferation under normoxia in LN229 cell with IC50 of 26 uM, markedly decreases HIF-1α protein synthesis induced by hypoxia or cobaltous ions in a dose- and time-dependent manner; inhibits phosphorylation of Akt, SAPK/JNK and Erk1/2, prevents the activation of HIF-1 target genes under hypoxia such as VEGF and Glut-1.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research Area——
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Indication——
Chemical Information
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CAS Number773852-25-8
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Formula Weight335.407
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Molecular FormulaC20H21N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tan C, et al. Cancer Res. 2005 Jan 15;65(2):605-12.
2. Belozerov VE, et al. Anticancer Drugs. 2005 Oct;16(9):901-9.
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