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HIF-IN-1
CAS No. 2393928-76-0
HIF-IN-1( —— )
Catalog No. M35415 CAS No. 2393928-76-0
HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 2MG | 105 | In Stock |
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Biological Information
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Product NameHIF-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionHIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.
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DescriptionHIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF
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Research Area——
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Indication——
Chemical Information
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CAS Number2393928-76-0
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Formula Weight260.29
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Molecular FormulaC17H12N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (38.42 mM; Ultrasonic (<60°C)
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SMILESO=C1C2=C(C=3C1=CC=CC3)C=NN2C4=CC=C(C)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fuse S, et al. Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity. Bioorg Med Chem. 2020 Jan 1;28(1):115207. ?
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