TP-0463518( TP0463518 )

Catalog No. M12216 CAS No. 1558021-37-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

TP-0463518
Note

Research use only, not for human use.
Brief Description

TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor.
Description

TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively; demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats, shows potential for treatment of renal anemia.
In Vitro

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In Vivo

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Synonyms

TP0463518
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

PHD1(human)|PHD2(human)|PHD3(human)|PHD2(rat)
Research Area

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Indication

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CAS Number

1558021-37-6
Formula Weight

431.829
Molecular Formula

C20H18ClN3O6
Purity

>98% (HPLC)
Solubility

DMSO: 110 mg/mL (254.73 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

ClC(C=C1)=CC=C1OC2=NC=C(CN3C(C(C(NCC(O)=O)=O)=C(O)CC3)=O)C=C2
Chemical Name

(1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

1. Hamada M, et al. Bioorg Med Chem Lett. 2018 Apr 16. pii: S0960-894X(18)30351-2.

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