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KC7F2
CAS No. 927822-86-4
KC7F2( KC7F2 )
Catalog No. M16641 CAS No. 927822-86-4
A small molecule HIF-1α translation inhibitor with IC50 of 20 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 49 | In Stock |
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| 25MG | 88 | In Stock |
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| 50MG | 161 | In Stock |
|
| 100MG | 237 | In Stock |
|
| 200MG | 309 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKC7F2
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule HIF-1α translation inhibitor with IC50 of 20 uM.
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DescriptionA small molecule HIF-1α translation inhibitor with IC50 of 20 uM; prevents the activation of HIF-target genes such as CA IX, MMP2, Endothelin 1, and Enolase 1; down regulates of HIF-1α protein synthesis by suppression of the phosphorylation of 4EBP1 and p70S6K.
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In VitroCell Cytotoxicity Assay Cell Line:MCF7 cells, LNZ308 cells, A549 cells, U251MG cells, LN229 cells Concentration:15–25 μM Incubation Time:0-72 hours Result:With cytotoxicity more pronounced in tumor cell lines as compared to normal cells.Cell Viability Assay Cell Line:LN229 cells Concentration:6 hours Incubation Time:0 μM, 5 μM,7.5 μM,10 μM,15 μM,20 μM,30 μM,40 μM,60 μM,80 μM Result:Decreases HIF-1α protein levels in a dose-dependent manner.
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In Vivo——
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SynonymsKC7F2
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF-1α
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number927822-86-4
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Formula Weight570.3812
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Molecular FormulaC16H16Cl4N2O4S4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESClC1=C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)C=C(Cl)C=C1
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Chemical NameBenzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Narita T, et al. Clin Cancer Res. 2009 Oct 1;15(19):6128-36.
2. Guan G, et al. Cancer Lett. 2015 Feb 1;357(1):254-64.
3. Cammarata PR, et al. Mol Vis. 2015 Sep 1;21:1024-35.
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