M1002( —— )

Catalog No. M35596 CAS No. 823830-85-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

M1002
Note

Research use only, not for human use.
Brief Description

M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.
Description

M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors.
In Vitro

M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy.M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors.RT-PCR Cell Line:786-O cells Concentration:10 μM Incubation Time:24 hoursResult:Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control.RT-PCR Cell Line:Hep3B cells Concentration:5 μM Incubation Time:24 hours Result:Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.
In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF
Research Area

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Indication

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CAS Number

823830-85-9
Formula Weight

394.29
Molecular Formula

C15H8F6N2O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (126.81 mM; Ultrasonic (<60°C); )DMF : 50 mg/mL (126.81 mM; Ultrasonic)
SMILES

FC(F)(F)C1=CC(=CC(NC2=NS(=O)(=O)C3=CC=CC=C23)=C1)C(F)(F)F
Chemical Name

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1. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.?

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