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M1002
CAS No. 823830-85-9
M1002( —— )
Catalog No. M35596 CAS No. 823830-85-9
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 241 | In Stock |
|
| 50MG | 358 | In Stock |
|
| 100MG | 516 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameM1002
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NoteResearch use only, not for human use.
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Brief DescriptionM1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.
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DescriptionM1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors.
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In VitroM1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy.M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors.RT-PCR Cell Line:786-O cells Concentration:10 μM Incubation Time:24 hoursResult:Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control.RT-PCR Cell Line:Hep3B cells Concentration:5 μM Incubation Time:24 hours Result:Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF
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Research Area——
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Indication——
Chemical Information
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CAS Number823830-85-9
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Formula Weight394.29
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Molecular FormulaC15H8F6N2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (126.81 mM; Ultrasonic (<60°C); )DMF : 50 mg/mL (126.81 mM; Ultrasonic)
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SMILESFC(F)(F)C1=CC(=CC(NC2=NS(=O)(=O)C3=CC=CC=C23)=C1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.?
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