HIF2α-IN-2( TCS 7009 | TC S 7009 | TC-S 7009 )

Catalog No. M11779 CAS No. 1422955-31-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HIF2α-IN-2
Note

Research use only, not for human use.
Brief Description

HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM.
Description

HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function; antagonizes HIF-2 heterodimerization and DNA-binding activity in vitro and in cultured cells, reducing HIF-2 target gene expression.
In Vitro

Cell Proliferation Assay Cell Line:HPF cells in hypoxic conditions Concentration:0-100?μM Incubation Time:72 hours Result:Showed greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions.
In Vivo

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Synonyms

TCS 7009 | TC S 7009 | TC-S 7009
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF/HIF Prolyl-hydroxylase
Research Area

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Indication

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CAS Number

1422955-31-4
Formula Weight

308.653
Molecular Formula

C12H6ClFN4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (162.00 mM)
SMILES

O=[N+](C1=C(NC2=CC(F)=CC(Cl)=C2)C=CC3=NON=C31)[O-]
Chemical Name

N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine

1. Scheuermann TH, et al. Nat Chem Biol. 2013 Apr;9(4):271-6.

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