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PT-2399
CAS No. 1672662-14-4
PT-2399( PT 2399 | PT2399 )
Catalog No. M12550 CAS No. 1672662-14-4
PT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 245 | In Stock |
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| 5MG | 223 | In Stock |
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| 10MG | 335 | In Stock |
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| 25MG | 607 | In Stock |
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| 50MG | 877 | In Stock |
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| 100MG | 1228 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePT-2399
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NoteResearch use only, not for human use.
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Brief DescriptionPT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.
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DescriptionPT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain; minimally affects a panel of 68 receptors, ion channels, and enzymes; specifically disassembles HIF-2 but not HIF-1 complexes, reduces the expression of HIF-2 target genes (VEGF, SERPINE1, IGFBP3, CCND1, TGFA, and SLC2A1), but not HIF-1 targets (CA9, PGK1, and LDHA); exhibits tumor growth inhibition in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models.
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In Vitro——
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In VivoAnimal Model:Mice with RCC tumorgraft Dosage:100 mg/kg Administration:Oral gavage; every 12 hours Result:More active than SU 11248, and inhibited tumor growth in several SU 11248-resistant tumors.
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SynonymsPT 2399 | PT2399
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research Area——
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Indication——
Chemical Information
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CAS Number1672662-14-4
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Formula Weight419.32
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Molecular FormulaC17H10F5NO4S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 200 mg/mL 476.96 mM
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SMILESN#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C(F)F)=O)C3=C2CC(F)(F)[C@H]3O)=C1
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Chemical Name3-[(1S)-7-(difluoromethylsulfonyl)-2,2-difluoro-1-hydroxy-indan-4-yl]oxy-5-fluoro-benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen W, et al. Nature. 2016 Nov 3;539(7627):112-117.
2. Cho H, et al. Nature. 2016 Nov 3;539(7627):107-111.
3. Ricketts CJ, et al. Cancer Cell. 2016 Oct 10;30(4):515-517.
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