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Home - Products - Angiogenesis - HIF/HIF Prolyl-hydroxylase - HIF-2α-IN-3

HIF-2α-IN-3

CAS No. 313964-19-1

HIF-2α-IN-3( —— )

Catalog No. M32959 CAS No. 313964-19-1

HIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 181 In Stock
2MG 93 In Stock
5MG 164 In Stock
10MG 259 In Stock
25MG 506 In Stock
50MG 759 In Stock
100MG 1032 In Stock
200MG 1376 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    HIF-2α-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    HIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.
  • Description
    HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent.
  • In Vitro
    HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    313964-19-1
  • Formula Weight
    335.66
  • Molecular Formula
    C12H6ClN5O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (37.24 mM; Ultrasonic )
  • SMILES
    [O-][N+](=O)c1cc(Nc2ccc3nonc3c2[N+]([O-])=O)ccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.?
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