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HIF-2α-IN-3
CAS No. 313964-19-1
HIF-2α-IN-3( —— )
Catalog No. M32959 CAS No. 313964-19-1
HIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 181 | In Stock |
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| 2MG | 93 | In Stock |
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| 5MG | 164 | In Stock |
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| 10MG | 259 | In Stock |
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| 25MG | 506 | In Stock |
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| 50MG | 759 | In Stock |
|
| 100MG | 1032 | In Stock |
|
| 200MG | 1376 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHIF-2α-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionHIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.
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DescriptionHIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent.
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In VitroHIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF
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Research Area——
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Indication——
Chemical Information
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CAS Number313964-19-1
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Formula Weight335.66
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Molecular FormulaC12H6ClN5O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (37.24 mM; Ultrasonic )
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SMILES[O-][N+](=O)c1cc(Nc2ccc3nonc3c2[N+]([O-])=O)ccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.?
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