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LJ 001
CAS No. 851305-26-5
LJ 001( LJ001 | LJ-001 )
Catalog No. M16184 CAS No. 851305-26-5
LJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 211 | In Stock |
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| 25MG | 424 | In Stock |
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| 50MG | 616 | In Stock |
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| 100MG | 863 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLJ 001
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NoteResearch use only, not for human use.
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Brief DescriptionLJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses.
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DescriptionLJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1; specifically intercalates into viral membranes, irreversibly inactivates virions while leaving functionally intact envelope proteins, and inhibits viral entry at a step after virus binding but before virus-cell fusion; specifically inhibits virus-cell but not cell-cell fusion.
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In VitroCell Viability Assay Cell Line:ST cells Concentration:0.782, 1.563, 3.125, 6.25, 12.5, 25, 50, 100, 200 μM Incubation Time:24 h Result:Showed slight cytotoxicity with a CC50 value of 146.4 μM.Western Blot Analysis Cell Line:ST cells Concentration:12.5 μM Incubation Time:12, 24 h Result:Decreased the expression of TGEV N protein and PDCoV N-protein at 24 h and markedly reduced TCID50 titers at 12 and 24 h.RT-PCR Cell Line:ST cells Concentration:12.5 μM Incubation Time:1, 6, 12, 24 h Result:Inhibited TGEV and PDCoV gene mRNA expression in a time-dependent manner.
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In VivoAnimal Model:Female BALB/c mice Dosage:20, 50 mg/kg Administration:Oral gavage or i.p.; daily for 7 days Result:Revealed no abnormalities except a slight elevation in serum cholesterol levels in the treated vs. vehicle control group.
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SynonymsLJ001 | LJ-001
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PathwayMicrobiology/Virology
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TargetInfluenza Virus
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RecptorInfluenza Virus
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Research Area——
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Indication——
Chemical Information
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CAS Number851305-26-5
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Formula Weight327.42
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Molecular FormulaC17H13NO2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (305.42 mM)
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SMILESO=C1N(CC=C)C(S/C1=C\C2=CC=C(C3=CC=CC=C3)O2)=S
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Chemical Name(5Z)-5-[(5-phenylfuran-2-yl)methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wolf MC, et al. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62.
2. Vigant F, et al. PLoS Pathog. 2013;9(4):e1003297.
3. Balmer BF, et al. J Virol. 2017 Jan 31;91(4). pii: e02181-16.
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