S119-8

Research use only, not for human use.

S119-8 (Influenza inhibitor S119-8) is a novel broad spectrum inhibitor of influenza virus replication (IC50=1.43 nM) by targeting the viral Nucleoprotein (NP).

S119-8 (Influenza inhibitor S119-8) is a novel broad spectrum inhibitor of influenza virus replication (IC50=1.43 nM) by targeting the viral Nucleoprotein (NP), with no detectable cytotoxicity (CC50>50 uM); also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, does not inhibit a non-influenza virus, VSV; exhibits synergistic combined with in vitro viral inhibition assays.

S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM.

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Influenza inhibitor S119-8

Microbiology/Virology

Influenza Virus

Influenza Virus

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443639-96-1

344.458

C23H24N2O

>98% (HPLC)

DMSO : ≥ 150 mg/mL 435.48 mM

CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3

Benzamide, 4-(1,1-dimethylethyl)-N-[4-(phenylamino)phenyl]-

(-20℃)

With Ice Pack

≥ 2 years