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NSC 19630
CAS No. 72835-26-8
NSC 19630( MIRA-1 )
Catalog No. M15787 CAS No. 72835-26-8
NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 31 | In Stock |
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| 10MG | 48 | In Stock |
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| 25MG | 98 | In Stock |
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| 50MG | 142 | In Stock |
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| 100MG | 211 | In Stock |
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| 200MG | 312 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC 19630
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
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DescriptionNSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM; shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB); dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated γ-H2AX and PCNA foci in human cells; delays S-phase progression and induces DNA damage; a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.
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In VitroCell Proliferation Assay Cell Line:Saos-2-His273, H1299-His175, SKOV-His175 and SKOV-His273 Concentration:25 μM Incubation Time:48 hours Result:Inhibited cell growth in a mutant p53-dependent manner, with survival rate of 18.5~39% in no doxycycline and 71.5~87.5% in doxycycline.Apoptosis Analysis Cell Line:Saos-2 and Saos-2-His273 cells Concentration:10 μM Incubation Time:48 hours Result:Caused a substantial increase in the fraction of cells with a sub-G1 DNA content in the presence of mutant p53.
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In Vivo——
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SynonymsMIRA-1
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number72835-26-8
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Formula Weight183.2
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Molecular FormulaC8H9NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (545.97 mM)
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SMILESO=C(C=C1)N(COC(CC)=O)C1=O
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Chemical Name1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30.
2. Saha MN, et al. Br J Cancer. 2014 Apr 29;110(9):2224-31.
3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26;280(34):30384-91.
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