Rev1-IN-5( —— )

Catalog No. M16530 CAS No. 908510-73-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Rev1-IN-5
Note

Research use only, not for human use.
Brief Description

Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM.
Description

Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM; binds to Rev1-CT at the RIR interface, inhibits mutagenic Rev1/Polζ-dependent translesion synthesis (TLS) in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

DNA Repair Protein
Recptor

DNA Repair Protein
Research Area

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Indication

——

CAS Number

908510-73-6
Formula Weight

403.541
Molecular Formula

C21H29N3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

1-acetyl-N-(3-(cyclopropylcarbamoyl)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)piperidine-4-carboxamide

1. Sail V, et al. ACS Chem Biol. 2017 Jul 21;12(7):1903-1912.

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