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YU 238259
CAS No. 1943733-16-1
YU 238259( YU238259 )
Catalog No. M13044 CAS No. 1943733-16-1
YU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 54 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 306 | In Stock |
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| 50MG | 532 | In Stock |
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| 100MG | 764 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1572 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYU 238259
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NoteResearch use only, not for human use.
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Brief DescriptionYU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects.
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DescriptionYU 238259 is a novel DNA double-strand break repair inhibitor that exhibits potent synthetic lethality in the setting of DNA damage response and DNA repair defects; specifically inhibits homology-dependent DNA repair (HDR), but not non-homologous end-joining (NHEJ), in cell-based GFP reporter assays; significantly delays tumor growth of BRCA2-deficient human tumor xenografts in nude mice.
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In VitroYU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss.
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In VivoYU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice.
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SynonymsYU238259
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorHDR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1943733-16-1
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Formula Weight459.95
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Molecular FormulaC22H22ClN3O4S
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Purity>98% (HPLC)
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SolubilityDMSO: 84 mg/mL (182.6 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESC1=CC(OC)=CC=C1S(=O)(=O)NCC1=CC=C(C(=O)NCCC2=CC=C(Cl)C=N2)C=C1
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Chemical NameN-[2-(5-Chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stachelek GC, et al. Mol Cancer Res. 2015 Oct;13(10):1389-97.
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