AOH1160

Research use only, not for human use.

AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).

AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA); selectively kills many types of cancer cells at below micromolar concentrations (mean GI50=330 nM) without causing significant toxicity to a broad range of non-malignant cells, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, and causes cell cycle arrest; suppresses tumor growth without causing significant side effects in mice, demostrates the potential as a broad-spectrum therapeutic agent for cancer treatment.

Cell Cycle Analysis Cell Line:SAEC, H524 Concentration:500 nM Incubation Time:6, 24 h Result:Caused cell cycle arrest.Increased in the sub-G1 population in neuroblastoma and small cell lung cancer cells.Western Blot Analysis Cell Line:SAEC, H524 Concentration:500 nM Incubation Time:6, 24, 48 h Result:Increased γH2A.X levels and activated caspase-3 and caspase-9.

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AOH-1160 | AOH 1160

Cell Cycle/DNA Damage

DNA Repair Protein

DNA Repair Protein

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2089314-57-6

396.446

C25H20N2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (252.24 mM)

C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CNC(=O)C3=CC=CC4=CC=CC=C43

N-(2-oxo-2-((2-phenoxyphenyl)amino)ethyl)-1-naphthamide

(-20℃)

With Ice Pack

≥ 2 years