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PFM39
CAS No. 1310744-67-2
PFM39( SML1839 )
Catalog No. M11247 CAS No. 1310744-67-2
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePFM39
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NoteResearch use only, not for human use.
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Brief DescriptionPFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.
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DescriptionPFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.
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In VitroPFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR). PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ.
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In Vivo——
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SynonymsSML1839
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number1310744-67-2
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Formula Weight219.262
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Molecular FormulaC10H9N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (456.08 mM)
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SMILESO=C1N=C(N)S/C1=C\C2=CC=C(N)C=C2
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Chemical Name(5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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