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HUHS-015
CAS No. 1453097-13-6
HUHS-015( HUHS015 )
Catalog No. M11950 CAS No. 1453097-13-6
HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 147 | In Stock |
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| 50MG | 243 | In Stock |
|
| 100MG | 411 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHUHS-015
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NoteResearch use only, not for human use.
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Brief DescriptionHUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM.
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DescriptionHUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM; significantly suppresses the growth of DU145 cells in vitro and in a mouse xenograft model.
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In VitroHUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells.
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In VivoHUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model.HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration. Animal Model:Nude miceDosage:32 mg/kg Administration:Subcutaneous injection; daily; 6 days Result:Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration.
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SynonymsHUHS015
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorPCA-1/ALKBH3inhibitor
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1453097-13-6
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Formula Weight318.3724
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Molecular FormulaC19H18N4O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 34 mg/mL
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SMILESOC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3
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Chemical Name1H-Pyrazol-5-ol, 3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakao S, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1071-4.
2. Mabuchi M, et al. In Vivo. 2015 Jan-Feb;29(1):39-43.
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