Cart
sales@molnova.com
RAD51-IN-17
CAS No. 2101739-18-6
RAD51-IN-17( —— )
Catalog No. M13337 CAS No. 2101739-18-6
RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
|
| 2MG | 32 | In Stock |
|
| 5MG | 52 | In Stock |
|
| 10MG | 85 | In Stock |
|
| 25MG | 169 | In Stock |
|
| 50MG | 276 | In Stock |
|
| 100MG | 445 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRAD51-IN-17
-
NoteResearch use only, not for human use.
-
Brief DescriptionRAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines.
-
DescriptionRAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines; also sensitizes aggressive metastatic TNBC to DNA damage induced by irradiation; a valuable research tool for developing combination therapies to overcome RAD51 driven resistance and relapse in a variety of cancers.
-
In VitroRAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple-negative breast cancer (TNBC).RAD51-IN-1 (10 μM) decreases the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation.RAD51-IN-1 (10 μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation.
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetDNA Repair Protein
-
RecptorDNA Repair Protein
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2101739-18-6
-
Formula Weight373.84
-
Molecular FormulaC22H16ClN3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (167.19 mM)
-
SMILES——
-
Chemical Name(E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.
molnova catalog
related products
-
Rev1-IN-5
Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM.
-
IACS-4619
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
-
ML216
ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively.
