Cart
sales@molnova.com
IACS-4759
CAS No. 1884209-99-7
IACS-4759( IACS4759 )
Catalog No. M12940 CAS No. 1884209-99-7
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameIACS-4759
-
NoteResearch use only, not for human use.
-
Brief DescriptionIACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
-
DescriptionIACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
-
In Vitro——
-
In Vivo——
-
SynonymsIACS4759
-
PathwayCell Cycle/DNA Damage
-
TargetDNA Repair Protein
-
RecptorDNA Repair Protein
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1884209-99-7
-
Formula Weight211.265
-
Molecular FormulaC10H17N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name3-((2-amino-5-methylpyrimidin-4-yl)oxy)-2,2-dimethylpropan-1-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.
molnova catalog
related products
-
6-Hydroxy-DL-DOPA
6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
-
HUHS-015
HUHS-015 (HUHS015)?is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM.
-
PFM39
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.
