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D-G23
CAS No. 1225141-73-0
D-G23( —— )
Catalog No. M10863 CAS No. 1225141-73-0
D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameD-G23
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NoteResearch use only, not for human use.
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Brief DescriptionD-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM.
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DescriptionD-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro; suppresses growth of BRCA1- and BRCA2-deficient cells (at >10 uM concentration).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number1225141-73-0
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Formula Weight354.41
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Molecular FormulaC19H22N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-((2-((2,5-dimethoxyphenyl)amino)quinazolin-4-yl)amino)propan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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