Cart
sales@molnova.com
D-G23
CAS No. 1225141-73-0
D-G23( —— )
Catalog No. M10863 CAS No. 1225141-73-0
D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameD-G23
-
NoteResearch use only, not for human use.
-
Brief DescriptionD-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM.
-
DescriptionD-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro; suppresses growth of BRCA1- and BRCA2-deficient cells (at >10 uM concentration).
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetDNA Repair Protein
-
RecptorDNA Repair Protein
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1225141-73-0
-
Formula Weight354.41
-
Molecular FormulaC19H22N4O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name3-((2-((2,5-dimethoxyphenyl)amino)quinazolin-4-yl)amino)propan-1-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
molnova catalog
related products
-
NSC 617145
NSC 617145 is a novel small-molecule, selective inhibitor of WRN helicase with IC50 of 230 nM.
-
6-Hydroxy-DL-DOPA
6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
-
RAD51-IN-17
RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines.
