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MLAF50

CAS No. 1417653-96-3

MLAF50( MLAF 50 )

Catalog No. M11744 CAS No. 1417653-96-3

MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

MLAF50
Note

Research use only, not for human use.
Brief Description

MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.
Description

MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays; inhibits chromatin localization of REV1 in cells after damaging DNA; binds to the same residues of REV1 UBM2 that interact with ubiquitin, indicating that MLAF50 can compete with the REV1 UBM2-ubiquitin interaction orthosterically.
In Vitro

——
In Vivo

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Synonyms

MLAF 50
Pathway

Cell Cycle/DNA Damage
Target

DNA Repair Protein
Recptor

DNA Repair Protein
Research Area

——
Indication

——

Chemical Information

CAS Number

1417653-96-3
Formula Weight

510.066
Molecular Formula

C15H12I2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)CCC1=CC=C(I)C(OC2=CC=C(O)C=C2)=C1I
Chemical Name

3-(3-(4-hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Vanarotti M, et al. J Mol Biol. 2018 Jun 2. pii: S0022-2836(18)30553-9.

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