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MLAF50
CAS No. 1417653-96-3
MLAF50( MLAF 50 )
Catalog No. M11744 CAS No. 1417653-96-3
MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMLAF50
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NoteResearch use only, not for human use.
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Brief DescriptionMLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.
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DescriptionMLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays; inhibits chromatin localization of REV1 in cells after damaging DNA; binds to the same residues of REV1 UBM2 that interact with ubiquitin, indicating that MLAF50 can compete with the REV1 UBM2-ubiquitin interaction orthosterically.
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In Vitro——
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In Vivo——
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SynonymsMLAF 50
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number1417653-96-3
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Formula Weight510.066
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Molecular FormulaC15H12I2O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)CCC1=CC=C(I)C(OC2=CC=C(O)C=C2)=C1I
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Chemical Name3-(3-(4-hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vanarotti M, et al. J Mol Biol. 2018 Jun 2. pii: S0022-2836(18)30553-9.
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