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IBR2
CAS No. 313526-24-8
IBR2( IBR 2 )
Catalog No. M14009 CAS No. 313526-24-8
IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 183 | In Stock |
|
| 50MG | 253 | In Stock |
|
| 100MG | 352 | In Stock |
|
| 200MG | 520 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIBR2
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NoteResearch use only, not for human use.
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Brief DescriptionIBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.
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DescriptionIBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM; disrupts RAD51 multimerization and inhibits RAD51-mediated HR repair, reduces RAD51 protein levels via proteasome-mediated degradation; inhibits cell growth and induces apoptosis in imatinib-resistant T315I-Ba/F3 cells; significantly prolongs animal survival in a murine imatinib-resistant CML model bearing the T315I Bcr-abl mutation.
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In Vitro——
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In Vivo——
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SynonymsIBR 2
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number313526-24-8
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Formula Weight400.496
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Molecular FormulaC24H20N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 150 mg/mL 374.54 mM
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SMILESC1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54
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Chemical Name2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhu J, et al. EMBO Mol Med. 2013 Mar;5(3):353-65.
2. Ferguson PJ, et al. J Pharmacol Exp Ther. 2017 Oct 23. pii: jpet.117.241661.
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