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Home - Products - Cell Cycle/DNA Damage - DNA Repair Protein - IBR2

IBR2

CAS No. 313526-24-8

IBR2( IBR 2 )

Catalog No. M14009 CAS No. 313526-24-8

IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IBR2
  • Note
    Research use only, not for human use.
  • Brief Description
    IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.
  • Description
    IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM; disrupts RAD51 multimerization and inhibits RAD51-mediated HR repair, reduces RAD51 protein levels via proteasome-mediated degradation; inhibits cell growth and induces apoptosis in imatinib-resistant T315I-Ba/F3 cells; significantly prolongs animal survival in a murine imatinib-resistant CML model bearing the T315I Bcr-abl mutation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    IBR 2
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Repair Protein
  • Recptor
    DNA Repair Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    313526-24-8
  • Formula Weight
    400.496
  • Molecular Formula
    C24H20N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 150 mg/mL 374.54 mM
  • SMILES
    C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54
  • Chemical Name
    2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhu J, et al. EMBO Mol Med. 2013 Mar;5(3):353-65. 2. Ferguson PJ, et al. J Pharmacol Exp Ther. 2017 Oct 23. pii: jpet.117.241661.
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