JW55( Tankyrase 1/2 Inhibitor IV )

Catalog No. M15535 CAS No. 664993-53-7

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Datasheet

HNMR

HPLC

MSDS

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Product Name

JW55
Note

Research use only, not for human use.
Brief Description

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.
Description

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.
In Vitro

——
In Vivo

——
Synonyms

Tankyrase 1/2 Inhibitor IV
Pathway

Metabolic Enzyme/Protease
Target

PPAR
Recptor

TNKS1| TNKS2
Research Area

Cancer
Indication

——

CAS Number

664993-53-7
Formula Weight

434.48
Molecular Formula

C25H26N2O5
Purity

>98% (HPLC)
Solubility

DMSO, Ethanol: 100 mM
SMILES

O=C(C1=CC=CO1)NC2=CC=C(C(NCC3(C4=CC=C(OC)C=C4)CCOCC3)=O)C=C2
Chemical Name

N-(4-(((4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamide

1.Waaler J, et al. Y Res. 2012 Jun 1;72(11):2822-32.

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