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BAY-0069
CAS No. 420826-65-9
BAY-0069( —— )
Catalog No. M36094 CAS No. 420826-65-9
BAY-0069 is a potent and selective PPARγ transactivator, inhibiting human PPARγ and murine PPARγ with IC50 values of 6.3 nM and 24 nM, respectively. BAY-0069 can be used in cancer research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | Get Quote |
|
| 5MG | 76 | Get Quote |
|
| 10MG | 122 | Get Quote |
|
| 25MG | 266 | Get Quote |
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| 50MG | 419 | Get Quote |
|
| 100MG | 621 | Get Quote |
|
| 500MG | 1305 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBAY-0069
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NoteResearch use only, not for human use.
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Brief DescriptionBAY-0069 is a potent and selective PPARγ transactivator, inhibiting human PPARγ and murine PPARγ with IC50 values of 6.3 nM and 24 nM, respectively. BAY-0069 can be used in cancer research.
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DescriptionBAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer.
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In VitroBAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM.BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9.Cell Proliferation Assay Cell Line:PPARγ-amplified cell line UM-UC-9 Concentration:0.0001, 0.001, 0.01, 0.01 and 1 μM Incubation Time:7 days Result:Inhibited PPARγ-amplified cell line UM-UC-9 with an IC50 of 2.54 nM.
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In VivoBAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CLb,hmic of 0.47 L/h/kg in human liver microsomes and CLb,rhep of 3.9 L/h/kg in rat liver hepatocytes.Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPAR
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Research Area——
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Indication——
Chemical Information
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CAS Number420826-65-9
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Formula Weight466.28
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Molecular FormulaC22H16BrN3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (214.46 mM; Ultrasonic (<60°C)
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SMILESN(C(=O)C1=CC(N(=O)=O)=CC=C1Br)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Orsi DL, Goldstein JT, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069. J Med Chem. 2022 Nov 10;65(21):14843-14863.?
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