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Oltipraz
CAS No. 64224-21-1
Oltipraz( RP 35972 | NSC 347901 )
Catalog No. M15443 CAS No. 64224-21-1
Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 48 | In Stock |
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| 25MG | 67 | In Stock |
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| 50MG | 83 | In Stock |
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| 100MG | 117 | In Stock |
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| 200MG | 150 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOltipraz
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NoteResearch use only, not for human use.
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Brief DescriptionOltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth.
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DescriptionOltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination; abrogates insulin-induced H(2)O(2) production, thereby preventing H(2)O(2)-enhanced HIF-1alpha expression and promoting its ubiquitination and degradation; inhibits HIF-1α activity and HIF-1α-dependent tumor growth both in vitro and in vivo.Steatohepatitis Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsRP 35972 | NSC 347901
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorReverseTranscriptase
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Research AreaOther Indications
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IndicationSteatohepatitis
Chemical Information
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CAS Number64224-21-1
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Formula Weight226.3416
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Molecular FormulaC8H6N2S3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESS=C1SSC(C2=NC=CN=C2)=C1C
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Chemical Name3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee WH, et al. Mol Cancer Ther. 2009 Oct;8(10):2791-802.
2. Kang SG, et al. Carcinogenesis. 2012 Mar;33(3):661-9.
3. Lee YH, et al. Bioorg Med Chem. 2016 Jun 15;24(12):2843-51.
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