IDF-11774( IDF 11774 | IDF11774 )

Catalog No. M11810 CAS No. 1429054-28-3

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Product Name

IDF-11774
Note

Research use only, not for human use.
Brief Description

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor.
Description

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells; suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α; inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells; exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.
In Vitro

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In Vivo

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Synonyms

IDF 11774 | IDF11774
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF/HIF Prolyl-hydroxylase
Research Area

Cancer
Indication

——

CAS Number

1429054-28-3
Formula Weight

368.521
Molecular Formula

C23H32N2O2
Purity

>98% (HPLC)
Solubility

DMSO : 60 mg/mL 162.82 mM
SMILES

O=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2
Chemical Name

2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one

1. Ban HS, et al. Bioconjug Chem. 2016 Aug 17;27(8):1911-20. 2. Ban HS, et al. Cell Death Dis. 2017 Jun 1;8(6):e2843.

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