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JNJ-42905343
CAS No. 1238689-36-5
JNJ-42905343( JNJ 42905343 | JNJ42905343 )
Catalog No. M10958 CAS No. 1238689-36-5
JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJNJ-42905343
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor.
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DescriptionJNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.
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In Vitro——
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In Vivo——
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SynonymsJNJ 42905343 | JNJ42905343
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research Area——
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Indication——
Chemical Information
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CAS Number1238689-36-5
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Formula Weight394.362
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Molecular FormulaC20H15FN4O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barrett TD, et al. Br J Pharmacol. 2015 Aug;172(16):4078-88.
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